SeneCell™ SenePlex+® StemCell Concentrate

1.66 fl oz / 49 mL
SKU: 3269
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Clinically proven to double skin cell renewal, deliver instant and lasting hydration, and visibly lift and firm — powered by 5 clinical-level actives in one lightweight, layerable formula. In an independent 8-week clinical study, 100% of participants saw measurable hydration improvement — immediately and over time. Real results. No appointment needed. 

Apply 2 pumps of SeneCell™ SenePlex+® StemCell Concentrate to clean face and neck, morning and night as your first skincare step after cleansing or exfoliating.

ORDER OF APPLICATION:

Cleanser → Climate Control → GLP Complex™ → SeneCell™ SenePlex+® StemCell Concentrate → Moisturizer → EyeCreme

100% HYDRATION RESULTS. IMMEDIATELY: Not a single participant was left out. Measurably more hydrated right after application, at 24 hours, at 48 hours, and still improving after 8 weeks.* 

56.4% HYDRATION IMPROVEMENT AFTER 8 WEEKS: Not just a one-time boost — skin hydration kept improving with continued use, reaching a 56.4% improvement after 8 weeks of consistent use.* 

DOUBLES CELL RENEWAL IN 18 DAYS: Contains our highest dose of SenePlex+®, which has been clinically proven to double skin cell turnover in 18 days.※ 

5× MORE PLUMPING POWER: Holds 5× more water than standard Hyaluronic Acid for visibly plumper, bouncier skin.⁑ 

FIRMS AND LIFTS AS LITTLE AS 14 DAYS: Clinically shown to firm sagging skin at the jawline and eyelids for a more sculpted, contoured appearance.† 

UP TO 29% FEWER WRINKLES IN 4 WEEKS: Clinically proven to reduce fine lines and wrinkles by up to 29% — with continued results on deep wrinkles over time.⁂ 

WORKS WITH EVERYTHING: Lightweight and layerable. Wear alone or mix into moisturizer or foundation for a luminous finish. 

CLEAN BEAUTY, ALWAYS: Made in the USA. Gluten-free, paraben-free, alcohol-free, cruelty-free, and vegan. 

Key Ingredients & Benefits

SenePlex+®‡: Clinically proven proprietary complex shown to double cell renewal (turnover) in 18 days and reduce the visible signs of aging ※

Marimoist® (Red Algae Extract) ‡ : A clinically proven blend of Red Seaweed Extract and Hyaluronic Acid shown to help deliver intense, long-lasting hydration and helps reduce water loss.*

SharoHyal® MOIST (Cross-Linked Sodium Hyaluronate) ‡ : Clinically proven advanced Hyaluronic Acid that forms a water reservoir and breathable hydration veil for a visible plumping effect.⁑

ChroNOline™ (Tetrapeptide-3)‡: Clinically proven peptide that helps improve firmness and smoothness while visibly reducing fine lines and wrinkles by up to 29% in 4 weeks.⁂

Orchistem™ (Orchid Stem Cell Extract) ‡ : Clinically proven to help visibly improve the appearance of sagging and drooping skin for a more contoured and lifted look. †

 ‡ When used at clinical levels. All Trademarks are property of their respective owners.

*Results based on an 8-week independent consumer perception study, measured by a self-assessment questionnaire. 

* Marimoist® (Red Algae Extract) Clinically proven to boost skin hydration by over 40% after just one application – and keep skin moisturized for 48 hours. Based on clinical studies by Marimoist® measuring skin hydration and barrier function in women with dry skin after a single application of the active ingredient and up to 8 weeks of continued use. This is not a SeneGence clinical study.

※SenePlex+® Clinically proven to accelerate skin cell renewal by 100% in just 18 days—twice the normal rate of the skin’s 28-day cycle.Based on 20-Day independent clinical study of thirty-three participants, women ages 19 to 65. Results are measured by expert clinical graded analysis compared to baseline.

⁑ SharoHyal® MOIST (Cross-Linked Sodium Hyaluronate) Over a 4-week trial, users observed improved skin tone and elasticity due to this plumping hydration effect. Based on SharoHyal® MOIST supplier testing during a 4-week clinical trial evaluating hydration, skin tone, and elasticity improvements compared to baseline. This is not a SeneGence clinical study.

⁂ ChroNOline™ (Tetrapeptide-3) Clinically proven peptide that visibly reduces fine lines and wrinkles by up to 29% in 4 weeks – and even tackles deep wrinkles with continued use. Based on a ChroNOline™ 56-day double-blind clinical trial of 27 women ages 40–65, with results measured against placebo. This is not a SeneGence clinical study.

† Orchistem™ (Orchid Stem Cell Extract) Clinically shown to firm sagging skin along the jawline and eyelids for a more youthful look. Based on two Orchistem™ in vivo clinical studies in women assessing lifting effect on jawline and eyelids after 14 days of use. This is not a SeneGence clinical study.

All Ingredients
Aqua/Water/Eau, Glycerin, Sodium Polyacrylate, Lecithin, Chondrus Crispus (Carrageenan) Extract, Lauroyl Lysine, Potassium Sorbate, Parfum/Fragrance, Sodium Hyaluronate Crosspolymer, Citric Acid, Ethylhexylglycerin, Benzyl Benzoate, Aloe Barbadensis (Aloe Vera) Leaf Juice, Trisodium Ethylenediamine Disuccinate, Gluconolactone, Hexamethylindanopyran, Linalool, Sodium Benzoate, Hydroxycitronellal, Geraniol, Sodium Hyaluronate, Citronellol, Alpha-Isomethyl Ionone, Caprooyl Tetrapeptide-3, Dextran, Tocopheryl Acetate, Panthenol, Butylene Glycol, Calanthe Discolor (Ebine) Extract, Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Xanthan Gum, 1,2-Hexanediol, Caprylyl Glycol, Calcium Gluconate, Laminaria Digitata (Kelp) Extract, Saccharomyces Cerevisiae (Yeast) Extract, Orchis Mascula (Orchid) Flower Extract, Phenoxyethanol, Urea*, Glucosamine HCl. Synthetic*

Overall rating: 4.911392 / 5 from 79 reviews.

AI Generated Review Summary

This advanced anti-aging serum is praised for making skin feel incredibly smooth and hydrated. Many customers appreciate its lightweight, layerable formula, suitable for all skin types, which helps achieve smoother, younger-looking skin without professional treatments.

Summary topics

  • Skin Hydration (23%): Many customers expressed appreciation for how this product made their skin feel incredibly smooth and hydrated.
  • Skin Feel (23%): A significant number of customers stated that the product feels great on their skin, making it a popular choice.

Review topics: [results, wrinkles, feels, smells, skin, look, face, difference, complexion, neck, become].

Review highlights

  • "I will say that application is easy, smells great, and feels good on my face."Katherine C.
  • "I love how my face and neck feel baby soft from this product, and I’m hooked."Ruth K.
  • "My skin soaked it up and after using it daily for the past few days, my skin has become incredibly smooth and hydrated."Kerrin D.

Reviews

No immediate results. I do

"No immediate results. I do like the feeling of this on my skin. It is very expensive."

Katherine M. (4/5)

I've only used it for

"I've only used it for 6 days so I can't quite tell yet. 😊"

Diane F. (5/5)

Fantastic

"Love this product, it’s really helping to smooth my skin"

Deborah L. (5/5)

I love so much, I

"I love so much, I ordered more!"

Sandy A. (5/5)

Love this product, highly recommended

"Love this product, highly recommended"

Anna S. (5/5)

Love this!!! Smells great too

"Love this!!! Smells great too"

Marci C. (5/5)

Saw difference starting within a

"Saw difference starting within a week!"

Vennesa C. (5/5)

I feel that this product

"I feel that this product really works to smooth out my skin."

Jennifer P. (5/5)

Feels light on your face.

"Feels light on your face."

Cheryl A. (5/5)

"Game changer for anti-aging skincare routine."

Ashley (5/5)

Q&A