SeneCell™ SenePlex+® StemCell Concentrate

1.66 fl oz / 49 mL
SKU: 3269
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Clinically proven to double skin cell renewal, deliver instant and lasting hydration, and visibly lift and firm — powered by 5 clinical-level actives in one lightweight, layerable formula. In an independent 8-week clinical study, 100% of participants saw measurable hydration improvement — immediately and over time. Real results. No appointment needed. 

Apply 2 pumps of SeneCell™ SenePlex+® StemCell Concentrate to clean face and neck, morning and night as your first skincare step after cleansing or exfoliating.

ORDER OF APPLICATION:

Cleanser → Climate Control → GLP Complex™ → SeneCell™ SenePlex+® StemCell Concentrate → Moisturizer → EyeCreme

100% HYDRATION RESULTS. IMMEDIATELY: Not a single participant was left out. Measurably more hydrated right after application, at 24 hours, at 48 hours, and still improving after 8 weeks.* 

56.4% HYDRATION IMPROVEMENT AFTER 8 WEEKS: Not just a one-time boost — skin hydration kept improving with continued use, reaching a 56.4% improvement after 8 weeks of consistent use.* 

DOUBLES CELL RENEWAL IN 18 DAYS: Contains our highest dose of SenePlex+®, which has been clinically proven to double skin cell turnover in 18 days.※ 

5× MORE PLUMPING POWER: Holds 5× more water than standard Hyaluronic Acid for visibly plumper, bouncier skin.⁑ 

FIRMS AND LIFTS AS LITTLE AS 14 DAYS: Clinically shown to firm sagging skin at the jawline and eyelids for a more sculpted, contoured appearance.† 

UP TO 29% FEWER WRINKLES IN 4 WEEKS: Clinically proven to reduce fine lines and wrinkles by up to 29% — with continued results on deep wrinkles over time.⁂ 

WORKS WITH EVERYTHING: Lightweight and layerable. Wear alone or mix into moisturizer or foundation for a luminous finish. 

CLEAN BEAUTY, ALWAYS: Made in the USA. Gluten-free, paraben-free, alcohol-free, cruelty-free, and vegan. 

Key Ingredients & Benefits

SenePlex+®‡: Clinically proven proprietary complex shown to double cell renewal (turnover) in 18 days and reduce the visible signs of aging ※

Marimoist® (Red Algae Extract) ‡ : A clinically proven blend of Red Seaweed Extract and Hyaluronic Acid shown to help deliver intense, long-lasting hydration and helps reduce water loss.*

SharoHyal® MOIST (Cross-Linked Sodium Hyaluronate) ‡ : Clinically proven advanced Hyaluronic Acid that forms a water reservoir and breathable hydration veil for a visible plumping effect.⁑

ChroNOline™ (Tetrapeptide-3)‡: Clinically proven peptide that helps improve firmness and smoothness while visibly reducing fine lines and wrinkles by up to 29% in 4 weeks.⁂

Orchistem™ (Orchid Stem Cell Extract) ‡ : Clinically proven to help visibly improve the appearance of sagging and drooping skin for a more contoured and lifted look. †

 ‡ When used at clinical levels. All Trademarks are property of their respective owners.

*Results based on an 8-week independent consumer perception study, measured by a self-assessment questionnaire. 

* Marimoist® (Red Algae Extract) Clinically proven to boost skin hydration by over 40% after just one application – and keep skin moisturized for 48 hours. Based on clinical studies by Marimoist® measuring skin hydration and barrier function in women with dry skin after a single application of the active ingredient and up to 8 weeks of continued use. This is not a SeneGence clinical study.

※SenePlex+® Clinically proven to accelerate skin cell renewal by 100% in just 18 days—twice the normal rate of the skin’s 28-day cycle.Based on 20-Day independent clinical study of thirty-three participants, women ages 19 to 65. Results are measured by expert clinical graded analysis compared to baseline.

⁑ SharoHyal® MOIST (Cross-Linked Sodium Hyaluronate) Over a 4-week trial, users observed improved skin tone and elasticity due to this plumping hydration effect. Based on SharoHyal® MOIST supplier testing during a 4-week clinical trial evaluating hydration, skin tone, and elasticity improvements compared to baseline. This is not a SeneGence clinical study.

⁂ ChroNOline™ (Tetrapeptide-3) Clinically proven peptide that visibly reduces fine lines and wrinkles by up to 29% in 4 weeks – and even tackles deep wrinkles with continued use. Based on a ChroNOline™ 56-day double-blind clinical trial of 27 women ages 40–65, with results measured against placebo. This is not a SeneGence clinical study.

† Orchistem™ (Orchid Stem Cell Extract) Clinically shown to firm sagging skin along the jawline and eyelids for a more youthful look. Based on two Orchistem™ in vivo clinical studies in women assessing lifting effect on jawline and eyelids after 14 days of use. This is not a SeneGence clinical study.

All Ingredients
Aqua/Water/Eau, Glycerin, Sodium Polyacrylate, Lecithin, Chondrus Crispus (Carrageenan) Extract, Lauroyl Lysine, Potassium Sorbate, Parfum/Fragrance, Sodium Hyaluronate Crosspolymer, Citric Acid, Ethylhexylglycerin, Benzyl Benzoate, Aloe Barbadensis (Aloe Vera) Leaf Juice, Trisodium Ethylenediamine Disuccinate, Gluconolactone, Hexamethylindanopyran, Linalool, Sodium Benzoate, Hydroxycitronellal, Geraniol, Sodium Hyaluronate, Citronellol, Alpha-Isomethyl Ionone, Caprooyl Tetrapeptide-3, Dextran, Tocopheryl Acetate, Panthenol, Butylene Glycol, Calanthe Discolor (Ebine) Extract, Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Xanthan Gum, 1,2-Hexanediol, Caprylyl Glycol, Calcium Gluconate, Laminaria Digitata (Kelp) Extract, Saccharomyces Cerevisiae (Yeast) Extract, Orchis Mascula (Orchid) Flower Extract, Phenoxyethanol, Urea*, Glucosamine HCl. Synthetic*

Overall rating: 4.939394 / 5 from 66 reviews.

AI Generated Review Summary

This advanced anti-aging serum is praised for making skin feel incredibly smooth and hydrated. Many customers appreciate its lightweight, layerable formula, suitable for all skin types, which helps achieve smoother, younger-looking skin without professional treatments.

Summary topics

  • Skin Hydration: 23%
  • Skin Feel: 23%

Review topics: ["results","wrinkles","feels","smells","skin","look","face","difference","neck","complexion","become"].

Review highlights

  • "I will say that application is easy, smells great, and feels good on my face."Katherine C.
  • "I love how my face and neck feel baby soft from this product, and I’m hooked."Ruth K.
  • "My skin soaked it up and after using it daily for the past few days, my skin has become incredibly smooth and hydrated."Kerrin D.

Reviews

Love this

"The packaging is great and the pump is very easy to use, and no waste of product with the airless pump. The product itself feels amazing on the skin and dries fast. I haven't been using it for long but I can already see and feel the difference in my skin."

Pauline T. (5/5)

I love the feel and

"I love the feel and softness it brings to my skin. The feel and look it brings my skin is amazing. It’s an awesome product!"

Kathy N. (5/5)

This product smells so nice.

"This product smells so nice. My face looks smooth and the results are noticeable. I really like this product."

Marie P. (5/5)

SeneCell SenePlex StemCell Concentrate

"SeneCell SenePlex StemCell Concentrate is super hydrating on my skin. My 61yr old skin is looking amazing. Highly recommended."

Karen B. (5/5)

Another important skin care product

"Another important skin care product that it's a must in my routine another ten our of ten"

Heather P. (5/5)

Good stuff

"This has really made a difference in my skin's appearance and feel. I really love it but the price point is very high"

Amy L. (5/5)

Wonderful product

"At 69 I am more confident with my skin. SeneCell has a wonderful feel and absorbs beautifully into my skin. I massage it in and also pat it into my face and neck."

Debra A. (5/5)

Senecell

"Noticed my deeper wrinkles have softened. My skin feels a lot more hydrated. I use 2 pumps morning and night coupled with my other skin care products. Overall I am happy with the results. Looking forward to seeing more results in the future with use."

Kelly-Anne B. (5/5)

It is absolutely wonderful! It

"It is absolutely wonderful! It helps my face so much!"

Tamra P. (5/5)

my complexion has really improved

"my complexion has really improved !"

Kathy G. (5/5)

Q&A