GLP Complex serum bottle with SenePlex+ and Exosomes, blue cap and beige label on a pale background with a She Finds 2026 badge.
Glossy blue gel blob on a light blue backdrop representing GLP Complex
SeneGence GLP Complex serum bottle with pump on a blue water background
Close-up of a smiling woman holding GLP Complex serum bottle against a pale blue background.
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP Complex serum bottle on a blue surface with Clinically Proven Ingredients text overlay.
Close-up of a smiling woman with clear skin and freckles showing skincare results
Close up of GLP Complex pump dispensing a pale gel onto the skin.
Three SeneGence skincare bottles arranged in a row forming the Triple Cell Renewal Trio.
SeneGence skincare trio on a blue backdrop featuring a facial mask, a 3 in 1 cleanser, and GLP Complex.
GLP Complex serum bottle with SenePlex+ and Exosomes, blue cap and beige label on a pale background with a She Finds 2026 badge.
Glossy blue gel blob on a light blue backdrop representing GLP Complex
SeneGence GLP Complex serum bottle with pump on a blue water background
Close-up of a smiling woman holding GLP Complex serum bottle against a pale blue background.
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP - Complex™ with SenePlex+® and Exosomes
GLP Complex serum bottle on a blue surface with Clinically Proven Ingredients text overlay.
GLP Complex application video.
Close-up of a smiling woman with clear skin and freckles showing skincare results
Close up of GLP Complex pump dispensing a pale gel onto the skin.
Three SeneGence skincare bottles arranged in a row forming the Triple Cell Renewal Trio.
SeneGence skincare trio on a blue backdrop featuring a facial mask, a 3 in 1 cleanser, and GLP Complex.

GLP Complex™ with SenePlex+® and Exosomes

Beauty editor-loved. Award finalist. No wonder it's flying fast!

1.66 fl oz / 49 mL
SKU: 3268
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A clinically proven, bio-intelligent facial serum designed to visibly restore volume, smooth deep wrinkles, and firm skin affected by aging, weight loss, and lifestyle shifts. Powered by peptides, lipids, and plant-based exosomes, this skin-adaptive formula delivered results in an independent 8-week clinical study — with 100% of participants seeing visible improvement in deep wrinkles and 81% showing measurable improvement in facial volume. 

Apply 2–3 pumps to clean, dry skin morning and evening. Gently press into areas that may look hollow or sagging—like the cheeks, under-eyes, smile lines, and jawline—then smooth over the face and neck. Follow with the rest of your skincare routine.

Recommended Order:

Cleanse → Climate Control→ GLP Complex™→ SeneCell Serum → Moisturizer → EyeCreme

Pro Tip:

For enhanced results, mix GLP Complex™ with Climate Control before applying.

G.L.P = GLOW. LIPIDS. PEPTIDES: Work synergistically to form a bio-intelligent ecosystem to complement the skin's natural ability to communicate and maintain its vitality. 

RESTORES LOST VOLUME: In an 8-week independent clinical study, 81% of participants showed visible improvement in facial volume, with an 8.4% improvement in facial fullness—helping skin look bouncier, more cushioned, and supported.*† 

WRINKLE SMOOTHING POWER: Clinically proven results—100% of participants showed visible improvement in the appearance of deep wrinkles, with a 23.4% improvement after just 8 weeks. Helps soften fine lines and even deep wrinkles for a refined, smoother complexion.*†§ 

PROVEN RADIANCE BOOST: After just 4 weeks, 87% of users noticed increased glow and radiance. Supports hydration, lipid balance, and barrier strength to promote skin that looks glowy, refreshed, and nourished—never tight or depleted.† 

FIRMER, MORE SUPPLE SKIN: 100% of users reported improved skin firmness and smoother skin texture at both 4 and 8 weeks, with up to 93% reporting skin that felt comfortable and supple throughout the day.* 

PLANT-DERIVED EXOSOMES: Help guide beneficial ingredients across the skin's surface, directing support where it's needed most to improve collagen performance, elasticity, and skin resilience.† 

EU-CLEAN, CONSCIOUS FORMULA: Vegan, cruelty-free, and free from parabens, sulfates, phthalates, PFAs, formaldehydes, gluten, and animal by-products. 

*Results based on an 8-week independent clinical study of 31 male and female participants, ages 38–75, measured by expert clinical analysis compared to baseline. Consumer perception results based on an independent self-assessment questionnaire after 8 weeks of morning and evening use. Individual results may vary. 

†Clinical studies on plant-derived exosome technology show improvements in skin texture, fullness, and overall appearance. These vesicles help support natural cell-to-cell communication, which can enhance skin hydration, smoothness, and visible radiance. These are not SeneGence clinical studies. Individual results may vary. 

‡SenePlex+® clinically proven to accelerate skin cell renewal by 100% in just 18 days—twice the normal rate of the skin's 28-day cycle. Based on a 20-day independent clinical study of thirty-three participants, women ages 19 to 65. Results are measured by expert clinical graded analysis compared to baseline. 

§Based on independent ingredient-level testing only. ChroNOline™ (Tetrapeptide-3) clinically proven peptide that visibly reduces fine lines and wrinkles by up to 29% in 4 weeks—and even tackles deep wrinkles with continued use. Based on a ChroNOline™ 56-day double-blind clinical trial of 27 women ages 40–65, with results measured against placebo. This is not a SeneGence clinical study. 

All trademarks are property of their respective owners. 

Key Ingredients & Benefits

Adipofill’in™ (Ornithine, Phospholipids & Glycolipids): A clinically tested biotech complex that helps support natural-looking volume in areas that may appear hollow or deflated, like cheeks and smile lines.*

Centella Asiatica Exosomes: Ultra-pure, plant-derived “messenger molecules” that help support collagen and elastin, improving the look of elasticity, resilience, and firmness.†

ChroNOline™ Peptide (Caprooyl Tetrapeptide-3): A clinically shown peptide that helps reduce the appearance of fine lines and wrinkles while supporting firmer, smoother-looking skin.§

SenePlex+®‡: A clinically proven proprietary complex shown to accelerate skin renewal, helping boost hydration, radiance, and overall skin performance.‡

Glycerin: A moisture-attracting humectant that hydrates and helps lock in softness.

Scent: A subtle, floral-inspired fragrance.

*Based on independent ingredient-level testing. In a 60-day split-face clinical (n=20; ages 40–60), the Adipofill’in™ side showed improved appearance of nasolabial folds and skin smoothness, with instrumental measures at 30 days indicating -9.5% wrinkle depth and -5.9% skin roughness vs. baseline/placebo. This is not a SeneGence clinical study. Individual results may vary.

 

† Clinical studies on plant-derived exosome technology show improvements in skin texture, fullness, and overall appearance. These vesicles help support natural cell-to-cell communication, which can enhance skin hydration, smoothness, and visible radiance.These are not SeneGence clinical studies. Individual results may vary.

 

‡ SenePlex+® clinically proven to accelerate skin cell renewal by 100% in just 18 days—twice the normal rate of the skin’s 28-day cycle. Based on 20-Day independent clinical study of thirty-three participants, women ages 19 to 65. Results are measured by expert clinical graded analysis compared to baseline.

 

§ Based on independent ingredient-level testing only. ChroNOline™ (Tetrapeptide-3) Clinically proven peptide that visibly reduces fine lines and wrinkles by up to 29% in 4 weeks and even tackles deep wrinkles with continued use. Based on a ChroNOline™ 56-day double-blind clinical trial of 27 women ages 40–65, with results measured against placebo. This is not a SeneGence clinical study.

 

All Trademarks are property of their respective owners.

All Ingredients
Aqua/Water/Eau, Glycerin, Sodium Polyacrylate, Lauroyl Lysine, Propanediol, Chondrus Crispus (Carrageenan) Extract, Lecithin, Potassium Sorbate, Sodium Hyaluronate Crosspolymer, Ornithine Hcl, Citric Acid, Parfum/Fragrance, Ethylhexylglycerin, Phospholipids, Benzyl Benzoate, Glycolipids, Aloe Barbadensis (Aloe Vera) Leaf Juice, Trisodium Ethylenediamine Disuccinate, 1,2-Hexanediol, Gluconolactone, Levulinic Acid, P-Anisic Acid, Sodium Hydroxide, Hexamethylindanopyran, Sodium Benzoate, Linalool, Hydroxycitronellal, Sodium Hyaluronate, Geraniol, Helianthus Annuus (Sunflower) Seed Oil, Tocopherol, Citronellol, Alpha-Isomethyl Ionone, Caprooyl Tetrapeptide-3, Dextran, Tocopheryl Acetate, Panthenol, Butylene Glycol, Calanthe Discolor (Ebine) Extract, Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Xanthan Gum, Caprylyl Glycol, Calcium Gluconate, Laminaria Digitata (Kelp) Extract, Saccharomyces Cerevisiae (Yeast) Extract, Orchis Mascula (Orchid) Flower Extract, Centella Asiatica Leaf Vesicles, Phenoxyethanol, Urea*, Glucosamine HCl. *Synthetic
Best Paired With
senecell-seneplex-stemcell-concentrate

SeneCell™ SenePlex+® StemCell Concentrate
View Details
 
Climate control product

Climate Control
View Details
 

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Overall rating: 4.980392 / 5 from 51 reviews.

AI Generated Review Summary

This facial serum is praised for its ability to visibly restore volume and smooth deep wrinkles. It is formulated with peptides, lipids, and plant-based exosomes, showing significant results in an 8-week clinical study. Users report their skin feeling softer and firmer.

Summary topics

  • Skin Feel: 38%
  • Skin Appearance: 25%

Review topics: [].

Review highlights

  • "Have only used a few times, but my skin feels nice and smooth after I've applied it." — Linda H.
  • "I’m in my sixties and my skin looks and feels softer , smoother and firmer especially around the Jaw Line ." — Inga K.
  • "Love that my face feel plump and healthier" — Connie G.

Reviews

GLP all the way!

"I have used the product for about a week. I am liking so far, I notice my deep deep wrinkles look more hydrated and that is a plus in my book!!! Can't wait to see what my skin is like a couple of months."

— Sandy A. (5/5)

This is a great product.

"This is a great product. I definitely have noticed a difference in one day and definitely noticed the difference the past week."

— Danielle D. (5/5)

Wonderful Changes

"I have seen amazing results in my skin. I combine it with my Climate Control and my face is so soft and glowing now."

— Sherry S. (5/5)

Gpl is amazing definitely a

"Gpl is amazing definitely a stayer in my skin care routine ten out of ten for me"

— Heather P. (5/5)

Just started using this product.

"Just started using this product. It does not irritate my skin, so I will continue to use it morning and night to see results."

— Karen W. (5/5)

I love it. It makes

"I love it. It makes my face feel so good! My face is looking better!"

— Nancy R. (5/5)

Have only used a few

"Have only used a few times, but my skin feels nice & smooth after I've applied it."

— Linda H. (5/5)

WOW!

"I have seen instant results in my skin both visually and by feel, the pump is very easy to use and love that there won't be any product wastage with the airless pump."

— Pauline T. (5/5)

I instantly felt my skin

"I instantly felt my skin tightening and it felt so fresh on my skin! I use it on my face, neck and décolleté."

— Cindy W. (5/5)

I just received the product

"I just received the product and haven't tried it yet."

— Pamela P. (5/5)

Q&A